One of the primary concerns about the widespread use of these drugs is that their properties are not fully understood, so that the degree of a threat that they pose for addiction, overdose, or other health consequences is uncertain. Indeed, the use of NPS has increased in recent years for each of the major classes of abused drugs, including opioids, cannabinoids, and stimulants (Graddy et al. One of the greatest concerns in the field of addiction (substance use disorders) has been the emergence of “new psychoactive substances” (NPS), referring to drugs whose widespread recreational or illicit use has only recently emerged as a public health problem.
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